研究领域

年龄相关性黄斑变性（AMD）是55岁以上人群视力出现不可逆性严重下降甚至盲目的首要原因。干性AMD是较为常见的类型，约占AMD患者总数的85−90%。Stargardt病（STGD）是一种遗传性青少年黄斑营养不良性眼病。由Abca4基因突变引起的STGD称为STGD1，呈常染色体隐性遗传，约占STGD患者总数的95%以上，全球患病率约为1/6578，STGD1患儿步入成年期时失明。本课题组主要从事干性AMD和STGD1的发病机制及其药物开发的研究。

学习经历

1998~2002  南京工业大学制药与生命科学学院 生物化工专业 工学学士

2002~2007  浙江大学化学系 化学专业 理学博士

工作经历

2007~2011  美国哥伦比亚大学 化学系/眼科系 博士后

2011~2015  浙江大学药学院 药理毒理研究所 特聘研究员、博导

2012~2015 浙江大学我院 附属第二医院眼科中心 特聘教授（兼）

2015~至今  双色球结果 眼科研究所 教授、博导

代表性成果（*通讯作者）

1. He D, Tao L, Cai B, Chen X, Wang Y, Li S, Liao C, Chen Y, Chen J, Liu Z*, and Wu Y*. eIF2α incites photoreceptor cell and retina damage by all-trans-retinal. J. Biol. Chem. 2023, 299(5), 104686.

2. Chen C, Yang K, He D, Yang B, Tao L, Chen J, and Wu Y*. Induction of ferroptosis by HO-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal. Free Radic. Biol. Med. 2023, 194, 245-254.

3. Cai B, Liao C, He D, Chen J, Han J, Lu J, Qin K, Liang W, Wu X, Liu Z, and Wu Y*. Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina. J. Biol. Chem. 2022, 298(2), 101553.

4. Chen C, Chen J, Wang Y, Liu Z, and Wu Y*. Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance. J. Biol. Chem. 2021, 296, 100187.

5. Liao C, Cai B, Feng Y, Chen J, Wu YP, Zhuang J, Liu Z, and Wu Y*. Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice. J. Biol. Chem. 2020, 295(20), 6958-6971.

6. Liao Y^#, Zhang H^#, He D, Wang Y, Cai B, Chen J, Ma J, Liu Z, and Wu Y*. Retinal pigment epithelium cell death is associated with NLRP3 inflammasome activation by all-trans retinal. Invest. Ophthalmol. Vis. Sci. 2019, 60(8), 3034-3045.

7. Gao Z, Liao Y, Chen C, Liao C, He D, Chen J, Ma J, Liu Z, and Wu Y*. Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina. J. Biol. Chem. 2018, 293(37), 14507-14519.                                         

8. Zhao J, Liao Y, Chen J, Dong X, Gao Z, Zhang H, Wu X, Liu Z, and Wu Y*. Aberrant buildup of all-trans-retinal dimer, a non-pyridinium bisretinoid lipofuscin fluorophore, contributes to the degeneration of the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 2017, 58(2), 1063-1075.

9. Liu X, Chen J, Liu Z, Li J, Yao K*, and Wu Y*. Potential therapeutic agents against retinal diseases caused by aberrant metabolism of retinoids. Invest. Ophthalmol. Vis. Sci. 2016, 57(3), 1017-1030.

10. Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, and Wu Y*. Involvement of endoplasmic reticulum stress in all-trans-retinal induced retinal pigment epithelium degeneration. Toxicol. Sci. 2015, 143(1), 196-208.

11. Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J, and Wu Y*. Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin. Invest. Ophthalmol. Vis. Sci. 2014, 55(12), 8241-8250.

12. Wu Y*, Jin Q, Yao K, Zhao J, Chen J, Wu X, Gan L, Li J, Song X, Liu X, and Cai X. Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'. Biochem. J. 2014, 460(3), 343-352.

13. Li J, Yao K, Yu X, Dong X, Gan L, Luo C, and Wu Y*. Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells. J. Biol. Chem. 2013, 288(50), 35671-35682.

14. Wu Y, Zhou J, Fishkin NE, Rittman BE, and Sparrow JR. Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid. J. Am. Chem. Soc. 2011, 133(4), 849-857.

15. Wu Y, Yanase E, Feng X, Siegel M, and Sparrow JR. Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc. Natl. Acad. Sci. USA 2010, 107(16), 7275-7280.

16. Wu Y, Fishkin NE, Pande A, Pande J, and Sparrow JR. Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease. J. Biol. Chem. 2009, 284(30), 20155-20166.

承担的国家级课题

1. 国家自然科学基金面上项目，82171064，2022.01-2025.12，主持

2. 国家自然科学基金面上项目，81870671，2019/01-2022/12，主持

3. 国家自然科学基金面上项目，81570857，2016/01-2019/12，主持

4. 国家自然科学基金面上项目，81271018，2013/01-2016/12，主持

5. 国家自然科学基金青年项目，21202146，2013/01-2015/12，主持

主要获奖/社会兼职/荣誉称号

1. 中华眼科学会奖（2018）

2. 厦门市重点人才（2017）

3. 中华医学会眼科分会青年委员（2016）

4. 福建省首批高层次引进人才（2016）